Latest article: |
Assembling Fragment Libraries
 22 Apr 2008: One of the key considerations when designing and assembling fragment libraries is the type of the screening platform that will be used to detect the interaction between the biological target and the fragment. This poster demonstrates the construction of two libraries of fragments. One library has been built for use in high-throughput biochemical screening assays and the other was purposefully designed for screening using NMR techniques.
Evotec technologies
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Recent articles: |
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Automated Evaluation of a Chemical Structure with Only 1D 1H and 2D 1H-13C HSQC
 18 Feb 2008: Standard 1H-13C HSQC 2D NMR spectra can now be measured quickly allowing for high-throughput evaluation of proposed chemical structures. This poster presents a method of automatic structure validation based on the comparison of calculated and experimental data for 1D 1H NMR and 2D 1H-13C HSQC spectra which increases the accuracy of the assignment process and the structure validation.
Advanced Chemistry Development, Inc., (ACD/Labs)
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Archiving NMR Data in an Electronic Lab Notebook World
07 Feb 2008: As many organizations shift their scientists away from traditional paper notebooks to electronic lab notebooks to promote productivity and information sharing, the meaningful retention of electronic data has never seemed more feasible. This application note highlights the benefits of having good NMR software tools that chemists can access, in the convenience of their own lab or office.
Advanced Chemistry Development, Inc., (ACD/Labs)
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Increasing Chemist Productivity in an Open-Access Environment
10 Dec 2007: This application note highlights the benefits of having good NMR software tools that chemists can access. It addresses NMR prediction and verification algorithms that can aid chemists in their interpretation of NMR data, thus accelerating the decision making process.
Advanced Chemistry Development, Inc., (ACD/Labs)
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CHN microanalysis - a technique for the 21st century?
19 Jun 2007: This technical paper demonstrates how CHN microanalysis offers a powerful and straightforward method for determining sample purity by providing a precise and accurate analysis of percentage carbon, hydrogen and nitrogen content.
Exeter Analytical (UK) Ltd.
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Identifying Metabolites in Biofluids
23 Mar 2007: This application note demonstrates how the process of identifying metabolites in biofluid spectra as part of a Chemometrics analysis can be significantly streamlined with the use the Chenomx Metabolite Database.
Advanced Chemistry Development, Inc., (ACD/Labs)
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Overlap Density Heatmaps: A Novel Approach to Metabolomics Research
15 Mar 2007: This study demonstrates the use of the novel Overlap Density Heatmap (ODH) tool, in the visualization and quantitative evaluation of 1H NMR spectra of human serum samples from diabetic and non-diabetic subjects.
Bio-Rad Laboratories Informatics Division
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Novel fermentation system for protein production and label incorporation for structural genomics
13 Mar 2007: Isotopic labelling of proteins, expressed in E. coli is a routine method in NMR supported structural genomics. Most widespread is the shaking culture on minimal medium M9 including required isotopes like 13C, 15N and/or 2H. Beside manpower the costs for isotopes are the most expensive factor of that process. This application note discusses the benefits of a novel micro fermentation system.
DASGIP
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Characterising Solid-State DNP
22 Dec 2006: DNP NMR yields greatly enhanced resonances in solution-state NMR spectra, overcoming the poor sensitivity of this very versatile analytical technique. To maximise the benefits that DNP NMR can offer, it is necessary to understand and optimise the solid-state polarisation. This application note presents a number of investigations into this process and discuss the implications for post-dissolution NMR measurements.
Oxford Instruments Molecular Biotools
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Working with Polymer NMR Spectra
29 Sep 2006: Polymer NMR spectra contain a unique set of challenges. Due to the different structural nature of the polymer, many of the rules for processing small molecule NMR spectra do not apply here. This application note explains the various aspects involved in working with polymer NMR spectra.
Advanced Chemistry Development, Inc., (ACD/Labs)
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